Acute and long-term pathological effects of COVID-19 on the placenta during second trimester and labor.

Background: COVID-19 pandemic has affected all the world. The consequence of infection causes many disorders in organs, one them is placenta. disease long-term effects on various tissues after recovery. aim this study was to investigate placentas pregnant women with healthy, positive during second trimester and labor.
 Material methods: A total twenty-four (8 patients per each group) were included study. Their processed for routine paraffin wax embedding protocol. blood parameters recorded. Placental stained hematoxylin-eosin dye immune TNF-α ADAMTS-8. Statistical analysis performed histological parameters.
 Results: AST CRP values biochemical higher labor groups than healthy group. Also, a significant increase ALT observed Normal histology patients. More histopathology recorded infected compared placentas. expression ADAMTS-8 found significantly non-COVID-19 group.
 Conclusions: can cause pathological changes pregnancy labor. This shows that not only acutely adverse placental pathologies but also effects. primary antibodies be guide demonstrating these